The Skourides Lab @ UCY

Cell Biology and Molecular Embryology

Text Box: Mitotic cell responses to substrate topological cues are independent of the molecular nature of adhesion. Anastasiou O, Hadjisavva R, Skourides A.P. Science Signalling Science Signaling  25 Feb 2020:Vol. 13, Issue 620, eaax9940 DOI: 10.1126/scisignal.aax9940 
Abstract: http://stke.sciencemag.org/cgi/content/abstract/sigtrans;13/620/eaax9940?ijkey=uJ2jeEBOiGwKM&keytype=ref&siteid=sigtrans 
Full text: http://stke.sciencemag.org/cgi/content/full/sigtrans;13/620/eaax9940?ijkey=uJ2jeEBOiGwKM&keytype=ref&siteid=sigtrans 
A simple mechanochemical model for calcium signalling in embryonic epithelial cells K Kaouri, PK Maini, PA Skourides, N Christodoulou, (2019) SJ Chapman Journal of mathematical biology 78 (7), 2059-2092

Methods of Calpain Inhibition to Determine the Role of Calpains in Embryo Development in Amphibians I Antoniades, A Charalambous, N Christodoulou, S Zanardelli, PA Skourides (2019) Calpain, 249-259

Determining Temporal and Spatial Expression of Calpains in Amphibians
A Charalambous, I Antoniades, N Christodoulou, S Zanardelli, PA Skourides. (2019) Calpain, 67-79

Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells. Antoniades, I., Stylianou, P., Christodoulou, N., & Skourides, P. A. (2017). Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M116.767111 
Petridou, N., Skourides, P. A ligand-independent integrin β1 mechanosensory complex guides spindle orientation. Nat Commun 7, 10899 (2016). https://doi.org/10.1038/ncomms10899 
Cell autonomous Ca2+ flashes elicit pulse contractions of an apical actin network to drive apical constriction during neural tube closure. N Christodoulou, PA Skourides - Cell reports, 2015.
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis. Petridou NI, Skourides PA. Nat Commun. 2014 Oct 24;5:5240. 
Antoniades I, Stylianou P, Skourides PA, Making the connection: ciliary adhesion complexes anchor Basal bodies to the actin cytoskeleton. Dev Cell. 2014 Jan 13;28(1):70-80. doi: 10.1016/j.devcel.2013.12.003.                                           F1000 Recommended
Maria Andreou,Chao Yun Irene Yan,Paris A. Skourides, 40LoVe and Samba Are Involved in Xenopus Neural Development and Functionally Distinct from hnRNP AB. PlosOne 2014 Jan 15
Petridou NI, Stylianou P, Skourides PA. A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis.
Development. 2013 Oct;140(20):4266-76. doi: 10.1242/dev.096073. 
Zanardelli S, Christodoulou N, Skourides PA. Calpain2 protease: A new member of the Wnt/Ca(2+) pathway modulating convergent extension movements in Xenopus..Dev Biol. 2013 Dec 1;384(1):83-100. doi: 10.1016/j.ydbio.2013.09.017. 
Ioannou A, Santama N, Skourides PA.Xenopus laevis nucleotide binding protein 1 (xNubp1) is important for convergent extension movements and controls ciliogenesis via regulation of the actin cytoskeleton. Dev Biol. 2013 Aug 15;380(2):243-58. 
Petridou NI, Stylianou P, Christodoulou N, Rhoads D, Guan JL, Skourides PA.Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos.
PLoS One. 2012;7(8):e42577. 
Comparing Intracellular Stability and Targeting of Sulfobetaine Quantum Dots with Other Surface Chemistries in Live Cells.  Muro E, Fragola A, Pons T, Lequeux N, Ioannou A, Skourides P, Dubertret B.  Small. 2012 Feb 29
Iro Eleftheriou, Andriani Ioannou, Andrea Lubatti, Anna Charalambous and Paris A. Skourides.(2011) High Resolution Whole Mount in Situ Hybridization Using Quantum Dot Nanocrystals. Journal of Biomedicine and Biotechnology (in press)

Maria Andreou, Iro Eleftheriou, Anna Eleftheriou, Neophytos Christodoulou, Ioanna Antoniades, Andriani Ioannou, Nicoletta Petridou, Panayiota Stylianou and Paris Skourides (2011) Evaluation of total toxicity of effluents from several waste water treatment stations and major water sources of Cyprus using Xenopus leavis as a model organism, Journal of Environmental Research And Development Vol. 6 No. 1, September 2011

Charalambous A, Antoniades I, Christodoulou N, Skourides PA. (2011) Split-Inteins for Simultaneous, Site-Specific Conjugation of Quantum Dots to Multiple Protein Targets In vivo. J Nanobiotechnology Sep 15;9(1):37.

Eleonora Muro, Pierre Vermeulen, Andriani Ioannou, Paris Skourides, Benot Dubertret, Alexandra Fragola and Vincent Loriette
Single-Shot Optical Sectioning using Two-Color Probes in HiLo Fluorescence Microscopy
Biophysical Journal Volume 100 May 2011 1–10

Lab Publications

! LATEST LAB RESEARCH : NEW Paper in Science Signalling

 

Older:  Paper in Nature Communications , Cover Article in  Developmental Cell